Product Name :
OTUB2 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
C14orf137 antibody Deubiquitinating enzyme OTUB2 antibody FLJ21916 antibody MGC3102 antibody OTB2 antibody OTU domain containing ubiquitin aldehyde binding protein 2 antibody OTU domain ubiquitin aldehyde binding 2 antibody OTU domain-containing ubiquitin aldehyde-binding protein 2 antibody OTU2 antibody 展开
Function :
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of ‘Lys-11′-,’Lys-48’- and ‘Lys-63’-linked polyubiquitin chains, with a preference for ‘Lys-63’-linked polyubiquitin chains. In the structure described by PubMed:15258613, the Asp-48 active site of the catalytic triad is located too far to interact directly with the active site His-224. A possible explanation is that OTUB2 is in inactive conformation in absence of ubiquitin and a conformation change may move Asp-48 in the proximity of His-224 in presence of ubiquitin substrate. Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).Formula of 261165-06-4
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human OTUB2. AA range:133-182
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of BnO-PEG4-OH Aliquot store at -20℃ or -80℃.PMID:33663276 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
27 kDa
Positive control :
Cervix carcinoma, Eye, Lung,