Product Name :
PARP1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
ADP ribosyltransferase (NAD+ poly (ADP ribose) polymerase) antibody ADP ribosyltransferase antibody ADP ribosyltransferase diphtheria toxin like 1 antibody ADP ribosyltransferase NAD(+) antibody ADPRT 1 antibody ADPRT antibody ADPRT1 antibody ARTD1 antibody msPARP antibody 展开
Function :
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR.2-chloro-4,6-dimethoxypyridine Purity Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.1035351-06-4 Purity Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.PMID:33618410
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within PARP1 aa 190-270.
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069165
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 113 kDa
Positive control :
Daudi, 293, A431, SH-SY5Y, K562.