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Skeletal fractures can occur when the loads imparted to the bone exceed its mechanical resistance. A bone’s mechanical properties are determined by each its structure (mass, geometry, architecture) as well as the material properties on the tissue itself, which include mineral and collagen matrix composition, microdamage accumulation, collagen cross-linking, and tissue hydration [1]. Clinical tactics to cut down fracture threat have focused nearly exclusively on enhancing bone mass, generally assessed by bone mineral density (BMD). FDA authorized antiresorptive agents like bisphosphonates and denosumab substantially cut down fracture risk mainly by decreasing osteoclast activity and bone turnover, thereby keeping or elevating bone density by rising mineralization [2]. Despite the fact that rising bone mass absolutely improves bone’s structural mechanical properties, adjustments in properties of your tissue itself may also substantially boost bone’s mechanical properties. Raloxifene can be a SERM (Selective Estrogen Receptor Modulator) made use of clinically in postmenopausal girls to slow bone loss and reduce fracture danger [3]. Raloxifene suppresses osteoclast activity and bone remodeling in a manner similar to estrogen via higher affinity interacti.